I started using bioidentical hormones in my late 40's for premenopausal symptoms. I am now in my 60's and continue to use them for menopausal symptoms. I really struggled before the bioidenticals and don't want to think of my quality of life without them. They make me feel like me and I am happily able to live my life fully. I would not ever consider "horse pee" hormones. I am content with the safety and excellent results with my bioidentical estradiol and progesterone.