I started taking hormones in my 40's when I started I have some perimenopause symptoms. I was having trouble sleeping and heavy flows. I was not feeling good. I have noticed substantial improvement through the years and continue to take them as I approach 60. I would not want to be without my bioidentical hormones. They have been the single most important thing I have done in my life for my health. I continue to have a healthy lifestyle of skiing and mountain biking due to my decision to take hormones. I am mentally and physically very healthy.