I started replacement with compounded biodenticals in my mid- forties for premenopausal symptoms and continued through menopause and continue even now on a daily basis. I will be 67 in April 2021. They have enabled me to live a better quality of life; no hot flashes, no mood swings, better sleep and energy, better aging, and a better sex life, which I attribute to these compounded medications. I would never use synthetic or uncompounded hormone replacement therapies or medications.