I spent two years in the most pain I was ever in, in my life. Finally after going to six different doctors I went out of the area (500 miles) to a doctor that I was diagnosed with Vulvodynua, and I.C. Within one month of using creams, atropine, estradiol and amit-baclocen the pain subsided. Since I was remarried five years prior to this issue, hormones were a blessing in our relationship. Now I see an endocrinologist and I'm now taking progesterone, and do not need Ambien to sleep. I have severe O.A. and have three back fusion shoulder replacements coming up in a month. I am going to use hormones to build back or at least slow this progression of OA. Without compounds I would be alone and in a wheelchair by now. Please don't mess with these compounds.