I am a breast cancer survivor & compounding my hormones is the safest & most effective way to treat my menopause symptoms. By having Bi-est compounded hormones, it mimics the estrogen found in my ovaries most naturally. This should be a persons choice to have hormones compounded. Please understand that hormones are not a “one size fits all”. Each individual person is different & through compounded hormones we can adjust our doses as needed.