I'm writing this for my 88 year old mom. She was having one intractable UTI after another due to an unstable pelvic floor from a hysterectomy and an allergy to cipro. She also was retaining urine in a bladder that was folded over by a ligament meant to keep organs no longer there in place. We tried self-catheterization which worked but was cumbersome and painful. Her Genito-urinary specialist finally ordered her estrase cream originally five times a week and now two times per week and it's made all the difference in the world. No more trips to the ER with fever, frequency and spasms. She has literally been UTI free since she has been using the cream vaginally and topically. We cannot thank the folks who compound the estrase enough for what they have done for her. I honestly am not certain she would be alive today without it.