I have tried so many hormone replacement pills, patches etc. None that ever helped! They actually made things worse! Then my doctor recommended that I go in the direction of bioidentical hormone replacement. I also I did a lot of reading/research and felt this was something I needed to try. That was 10 years ago and since I have not had one bad experience and my quality of life has changed for the better! No more headaches, night sweats, weight gain, and so many more symptoms that went away! If this were to be taken away, it would be detrimental to my daily life!