I have the vigor I had over 15 years ago. I have had no ill effects - hard to compare what would have happened, when it didn't! Dementia runs in my mother's family (she, her sister, and her two brothers had it early and were all killed by it). I am fine at the age of 68. So, I would ask the FDA, what group representing Big Pharma is pushing this? Typical prescription drugs have had a worse effect on many other people in my life than my compounded pharmaceuticals have had on me or my husband, who has used them for hormone replacement and topical pain control.