I have taken compounded hormones since my mid-50's when I first began to experience menopausal symptoms. My doctor prescribed the compounded hormones to be able to closely prescribe what my body needed and not what and otc product would provide. My doctor has modified the compounds through the years based upon levels showing up in my bloodwork giving me just what I need, not less, not more. I have never had any unpleasant symptoms since taking the compounded hormones. I have seen other women suffer from menopausal symptoms. I'm appreciative of my health and lack of symptoms.