I have my bloodwork done and the hormones are made for just me. I have had terrible hot flashes that greatly affect my quality of life. The hormone replacement has taken care of not having the hot flashes. I have had normal mammograms/uterus ultrasounds and bone density tests and all have been normal. I have been on these hormones for over 15 years. At one point I stopped, thinking I no longer needed them, and my hot flashes were back within two weeks. I feel I have very monitored care from my doctor and pharmicist. When I see a gynocologist, they want to put me on anti-depressants for my hot flashes. That makes no sense to me. I am not able to talk to some of my doctors about being on HRT. They shut down right away. I do not feel that they have done the research on them. If I ever do have any issues or questions my HRT pharmacist is always available for consultation and has always been able to help me. My doctor too. I will be 68 years old and I hope to be able to take these for the rest of my life.