I have hot flashes every hour with out these hormones and they need to be adjusted periodically by minute amounts. My body is extremely sensitive. I also have compounded T3 (thyroid hormone) and hydrocortisone. My body doesn't make these and the pharmaceutical equivalents (cytomel and cortef) make me rush and crash several times a day like taking speed. This leaves me bed bound as my body won't take that, my muscles won't move. I need compounded hormones to have any quality of life. Not all of our bodies fit the conventional mold. Those of us at the edges of the bell curve have a right to survive too. Big Pharma you have plenty of income you don't need to take this away from us to survive but we need this for our life and the pursuit of happiness in our quality of life.