I have been using compounded hormones estradiol and progesterone for the last seven years. I completed intense research prior to taking. You cannot substitute this method of delivering NATURAL biodentically matched hormones. Using the pharmaceutical method does NOT work for me and creates extreme side effects. I cannot take them. My health will decline severely if I am not able to access compounded hormones. I have nothing but positive effects from using compounded hormones and pray I can continue.