I have been using cBHT for 20 years, beginning in my early 50's, post-menopause, to deal with the 40 hot flashes I'd been having every day for several years. It saved my life, my sanity, and I believe has contributed to mental and physical health, youthfulness, vigor, clarity ever since. I have never had a single negative effect. I use a topical cream application, so I know there are no liver toxicity issues or other bodily tissue issues. For "fun", I tried stopping about five years ago just to see if I'd feel any different: within 2 weeks, I experienced hot flashes and palpable brain fog and loss of mental focus! I would be devastated if I had to stop using my HRT. Thank you.