I have been using bioidentical hormones for close to 20 years. This has been a protection against osteoporosis for me. I had an issue with reoccurring bladder infections 20 years ago. Since using the compounded estriol suppositories, I have not had one bladder infection. I have never had any adverse reactions from these compounded hormones. I am pleased that I am able to have the bioidentical hormones available to maintain hormonal balance in my body without any side effects.