I have been taking Compounding Hormone Replacement for 20 years or more. I believe the fact that I have remained very healthy, is due to the compounding hormones I have taken. Additionally, I have remained fairly active and eat primarily a healthy diet. I am on NO medications. I have had osteopenia of the hips for several years, which has not advanced to osteoporosis. I have very fibrocystic breast but no diagnosis of pre-cancer or cancer. I am petite, weighing 90 pounds, give or take a couple of pounds. Therefore, adding weights and resistance to my strength training has helped me to avoid osteoporosis. I will continue on Compounding Hormones unless my GYN advises otherwise. I have seen a few GYN doctors over the years and each has approved my taking the hormone replacement. I get regular checkups. I am extremely happy with the Compounding Pharmacy I have used. I met the owner years ago and their quality and service have remained outstanding. You can always talk on the phone to a live representative and they are very responsive to any request.