I have been taking cBHT for over 15 years to alleviate menopause symptoms. Twice I have stopped taking cBHT as a test to determine if the medications were still needed. Almost immediately, my symptoms came back. So, my plan is to take cBHT for the remainder of my life. As a vegan, Premarin is not an option for me. If cBHT were not available to me, I would not take synthetic hormones, therefore, my quality of life would definitely be changed in a negative way. It would impact my sleep, mood and most likely my relationships.