I have been on physician prescribed bioidentical compounded hormone therapy on and off for many, many years. My doctors always keep close watch on my lab work and adjust as needed so I always feel safe. Most recently I NEED these prescribed hormones for Osteoporosis. I am very small boned and 79 years old. My doctor has adjusted the dose three times in a year to be sure I am getting just what I need and no more. PLEASE DO NOT remove these from the available treatments for people like me. I do not feel poisoned like I would on many of the pharmaceutical treatments for osteoporosis with their nasty side effects and huge cost.