I started taking compounded progesterone at 34 due to severe PMS after the premature birth of my son. I took them for 5 years. Better for 5 years. Then perimenopause hit and I had to take it again. After my hysterectomy at 55, I had to take estrogen and progesterone. I have been on both since then. My depression is hormonally based. I have tried the synthetic ones and am allergic to them. If I cant get compounded bioidentical hormones, I will be severely depressed. Please do not restrict what we need.