I have been on compounded estradiol for approximately 15 years. It has drastically changed my life. Prior to my use of this, I was experiencing extreme night sweats, drastic mood swings, lethargy, memory problems and irratability. Almost immediately, I experienced a reduction in all symptoms, and eventually, the medication eradicated all of them. There have been two times in the last 15 years I have gone off the compounded estradiol and both times the symptoms returned immediately. I would not want to live without this option. Based on my experience with compounded estradiol, I know that it has a positive outcome and urge you to continue this valuable and much needed form of medication. Thank you.