I have a vaginal caruncle. It started out angry, red and prohibited me from having intercourse with my husband. In September, I began using the compounded estrogen cream and five months later, it now is non-threatening and sex has resumed. My numerous allergies require me to have a specially compounded formula so as not to have an allergic reaction, DOWN THERE! That happened to me once before with an over the counter and never again! Both my husband and I are forever grateful for this compounding pharmacy. Additionally, I had used compounded estrogen for many years in the past, experiencing no problems with my multiple allergies. It has been a lifesaver!