I had vaginal dryness and the normal Big Pharma vaginal cream prescribed did no good, but the bioidentical hormones set back the clock and I am still having well lubricated and enjoyable sex at 75 years age. My sister also used the same bioidentical estradiol and progesterone creams and had her bone density go from osteopenia to normal bone density. Bioidentical hormones didn't cause problems. Horse piss Premarin Estrogen and artifical Progestrone did. They threw out the baby with the bathwater because the bioidentical hormones did not cause the problems. Un-opposed estrogen caused a problem because it must be countered with real progesterone not Progestin. These should not be illegal just because Big Pharma can't make money on them. I had an ultrasound just recently, and everything is good: ovaries, uterus- no problems.