I had to have a hysterectomy after my 3rd child. My sister had breast cancer and so they took my ovaries too. I was on estrogen in a pill at first but I was short tempered and irrationally paranoid about everything. I told my doctor and he said to try a compound. I was back to normal. I have tried to go off of it several times with the same results....crazy Mama.... Its not like I am on a dangerous drug. It is a natural replacement that lets me be me.