I had taken medically prescribed HRT for 22 years and suddenly developed blood clots. This left me with no relief for hot flashes and sleepless nights. I started taking compounded HRT two years ago and have 100% relief. I was never verified "allergic", only a guess that the blood clot that almost killed me was caused by traditional HRT. I think 100% of women would benefit 100% of the time from compounded HRT. No harmful ingredients and 100% effective.