I suffered from endometriosis and had to have a total hysterectomy. I am now 46 years old and went through 15 years of not having adequate hormone replacement until I turned 40 and found a clinic that checked my bloodwork. That is when I found out there was no detectable levels of testosterone or progesterone in my blood and my Estrogen levels were through the roof while my Estradiol levels were low. It took one year to start to see improvements in my quality of life. I felt that I was done a disservice by my doctors for 15 years because no one bothered to check ALL my hormone levels. This is a critical therapy for women like me who lose their ovaries at such a young age.