I had successfully used cBHT for post-menopausal issues, including bone density loss, memory loss, very low muscle mass retention, and for depression/mood. The low doses I was on seemed to even out my life. My insurance stopped covering cBHT, so I tried other prescription alternatives instead of paying the $150 + for my usual meds. My marriage almost fell apart because of the physical and emotional roller coaster these different meds put me on. I am 61 years old. I started post-menopausal bleeding daily, I had low abdominal cramps and my breasts were terribly swollen and sore. I felt mildly depressed and anxious all the time. My blood levels came back as normal. This lasted for four months! I finally went back on the compounded meds and my life is back to normal. Fortunately, my insurance consortium was able to override my insurance and cover my compounded medications. What a disaster that could have been!