I had so many difficulties going into menopause - sleeplessness, hot flashes, and brain fog. The constantly being hot was more than I could manage with my career. The mood swings were testing my family. After beginning the compounding hormone replacement, after working with the compound pharmacist over several months, I had improved in all the areas of symptoms, most notably the constantly being hot. I have felt better with this treatment than I did taking estrogen pills and I do think I have benefitted from the use as I continue to age. It would have negatively impacted my life - as it did before I began the correct dosage if I had not been able to have this to use. The science may not always support the use of this - but the factors that I know improved certainly would and how one feels is very important in how you manage your life and being able to handle work and home and family - there are no breaks in what you need to do. This has helped me immensely!