I had serious side effects from premarin, made from pregnant horse urine. I had almost constant debilitating migraines. Even before my hysterectomy, prempro- pregnant horse urine with provera, massive bleeding and almost constant debilitating migraines. I had to wear a tampon, maternity pad and pad the bed and the seat of my car. The blood would run down my leg. Provera should be outlawed. I also have osteopenia and cannot tolerate the osteoporosis meds. Compounded hormones gave me my life back, 100% normal me again. Bioidentical to my body. No more migraines. I don't have to worry about getting cancer as a side effect. I can take this medication until the day I die for my osteopenia to try and prevent osteoporosis without the terrible side effects of those other medications. I cannot begin to even explain my relief when my doctor started me on the compounded hormones. I'm a nurse, I did my homework, research. Not only is premarin not good for women, look it up online. It is inhumane and abusive to the horses too. I suffered before I was on compounded hormones. The thought of losing them infuriates me. I know where it's coming from. There are plenty of women who have no side effects from the premarin but there should be compounded hormones on the market for those of us who can't tolerate it.