I had previously used HRT via oral pharmaceutical route with ill effects. I went to an integrative physician who prescribed the topical hormone as well as compounded thyroid replacement. Those interventions made a huge improvement in my overall health and well being. My daughter had a thyroidectomy and could not tolerate the synthetic thyroid hormone. She would not have made it without compounded thyroid and alternatives to pharmaceuticals. My husband is currently on a very specific compounded thyroid hormone and it has made a significant improvement over Synthroid. He has been on the compounded hormone for years and doing very well.