I need these hormones because they are one quarter as strong as the Estring estrogens and I need to use a local estrogen to avoid UTIs. My breast cancer was estrogen and progestroren positive. Tamoxofin , hormone fighting treatment I need to take, causes vaginal dryness, which I have had for many years. Also, the Estring which I have used for many years is now a $200.00 co pay every 3 months. UTIs can cause death.