I had both of my ovaries removed when I was only 35. None of the "traditional" pharmaceutical HRT products worked for me. I was severely depressed and suicidal. I was unable to focus enough to work (I was a technical writer). I quit driving after a couple of near misses with other vehicles. I was referred to a specialist in bioidentical HRT by my therapist. Within 48 hours of my first dose my brain turned back on. My kids called it my "happy mommy medicine". Bioidentical HRT literally save my life! I still take my troches daily and can't imagine what my life would look like without them!