I had bloodwork completed, indicating I had zero Estrogen and was experiencing 24x7 heart palpitations, combined with hot flashes, hair loss and vaginal dryness. My heart palpitations prevented any type of sleep. No sleep medicines, no CBD oil, no anti-anxiety meds, stopped the palpitations. Only Estrogen has given me symptom relief. I cannot take oral Estradiol due to other co-infections and creams peak and trough at three-four hours. Pellets are the only thing that are consistent and they must be compounded. Otherwise I have no quality of life. I am currently on SSDI due to this hormonal imbalance.