I had all the symptoms when I went through menopause. Palpitations, depression, anxiety, insomnia and hot flashes. I started taking Prempro and it gave me headaches everday. In search for something better I found cHRT and never looked back. I've been on these hormones for 20 years. Since I've been on them I've never had a bad mammogram and breast cancer runs in my family. 69 years old and feeling great!