I had a total hysterectomy years ago and have NEVER been able to be without hormones to control both hot flashes, depression and memory fog. I can no longer use regular prescription strengths as they are too strong for me at my age. Only the small amount made in the compounded formula works for me. Without that, I truly believe I'd be living as someone with dementia, depression and the horrible hot flashes that are 24/7 and never let up. I really don't know what I would do without it. It scares me to death that I might have to experience that.