I had a total hysterectomy in 2005 at age 44. Not a single doctor explained the ramifications that the loss of natural hormone production would have on me mentally or physically. I tried prescribed FDA approved hormones through my primary doctor and gynecologist (Premarin, etc.) but continued to experience chronic systemic inflammation, chronic insomnia, profuse am/pm sweats, muscle loss, chronic weakness and fatigue which eventually lead to a nervous breakdown and suicide attempts. HRT has restored me and given me back my life. I don't know where I'd be without it.