I had a total hysterectomy in 1981 at the age of 31, I was placed on Premarin but had difficulties with it. I am now 71 have been on ERT since 1981. Due to my age and the increased risk of stroke and cardiovascular disease, I am using compounded Estriol with good results. Please do not take this away from me as at the age of 71 menopausal symptoms greatly reduce my quality of life.