When severe bleeding (that could not be stopped) left me with a complete hysterectomy at 30, my doctor placed me on Premarin. After 10 years and a move, I met a doctor who suggested I try bio-identical hormone therapy instead of Premarin, because of side effects and risks. After a few months of tweaking levels, I was placed on a cream of estrogen blends and an oral progesterone capsule. These medications have treated me very well, eliminating migraine headaches, dense breast tissue, and a much better emotional outlook. Now in my 60’s I continue to have my levels tested and adjusted as needed, without the fears and side effects associated with a synthetic or horse derived product. My compounding pharmacy works well with my physician to assure my levels are balanced to keep me healthy and happy.