I had a hysterectomy in my late forties and received conventional HRT afterwards. Within a few weeks I started to feel bad, depressed, a lack of energy, and began to experience other symptoms that are "supposed" to go away with HRT but did not (like brain fog etc). After complaining to my doctor, who has seen the difference between patients on bio and patients on synthetics, he recommended that I try to change to bHRT. He did warn me that insurance usually does not cover it, but I was so miserable I decided to give it a try. Ever since then, I do not even remember that I am supposed to be post menopausal. I am healthy, still working full time at age 67 and have a better brain function and stamina than many of my, much younger co-workers. Also, I have a genetic tendency for Osteo, but over the years the decline is negligible inspite of my sedentary (i.e. office work) lifestyle. I do not know what I would do if I could not have access to my bHRTS. It would be devestating for me.