I had a hysterectomy in 2007 at the age of 55. I started taking Prempro, which I didn't like. The fact they were using horse urine was one of the reasons I stopped taking it. Plus I didn't like the way it made me feel and I try to limit what I take orally. I then started using estradiol patches and a compounding progesterone cream in 2008. I still use these today. I feel my hormones are balanced. I tried progesterone orally and didn't think it was doing anything. I can actually feel the cBHT progesterone cream working after I apply it. I have also tried other compounding pharmacy progesterone creams that didn't do anything. I don't have a uterus but using estradiol and progesterone makes me feel good. I have also tried just taking using the estradiol alone but always went back to getting the progesterone cream.