I had a hysterectomy due to endometriosis at age 30. By my late 30's, I was experiencing intolerable menopausal symptoms. I tried every form of estrogen/progesterone replacement therapy available from pharmaceutical companies, including Premarin and various patches, without relief. Premarin actually made me feel worse. I finally found a physician who recommended compounded estrogen and progesterone - the dose could be adjusted to my needs. I felt better immediately, though it took a few years to get things balanced correctly for me. Neither I nor my husband can imagine going back to the misery of how I felt before compounded HRT was available to me.