I had a hysterectomy at age 32. Began the artificial hormone therapy and stayed on them for years. Still had hot flashes and mood swings, not to mention when I heard how they were made it made me ill. The cruelty to those mares. Being a horse lover I was angry. I stopped the Premarin and discovered Bio identical compounded formulas. They were designed just for me, not generic. Big difference. All my symptoms went away. I slept, had energy and I thrived. Do not regulate our hormones. How and what medications we take is our constitutional right.