I experienced severe post-menopausal symptoms following cancer treatment and surgical menopause. I was unable to take the pill form/pharmeceutical hormones, due to side affects and increased cancer risk. I tried the E-string insert for seven years at substantial cost with only minor improvement in comfort. For just over a year now, i sought help from holistic practioners who prescribed estriol suppositories and progesterone cream which have significantly improved my comfort, and therefore quality of life.