I tried the traditional estradiol patch when menopausal and even using just 1/8th of the patch the hormones had me jumping out of my skin, created irritability and hyper activity, stressed my nerves. Found a functional Gynocologist MD who gave me bio identical and had absolutely no side effects and they did the job beautifully, I was able to sleep again, not be spaced out or irritable and my body loved the bio identical. We have since been able to reduce and change the prescription and I am still doing great on them 12 years later. I had the same negative side effects when I was young and tried to the the birth control pill. Bio identical are far more gentle yet still do a fabulous job and can be altered in dosage very easily.