During menopause I started having trouble sleeping . I would wake up during the night numerous times with hot flashes . I soon became very tired and irritable! I would also have hot flashes during the day when I was trying to work. I had to wait months before I could get into PA who could prescribe Biest cream. I felt like a new person. I could not believe the difference it made. I recently drove 9 hours to babysit my grandkids for 5 days. Unfortunately I forgot my prescription at home. I could not believe how irritable I was without it. I felt bad that I was not as patient with the children like I normally am. I cannot imagine not having access to my prescription that is formulated just for me. I have been on my current prescription for probably 5 years.