I can't imagine my life without bioidentical hormone replacement therapy. I'm chronically low on most of hormones, especially progesterone. I would not be able to have the life I do without them now. I have been taking them for over 15 years with only benefits, including but not limited to, great bone density at age 65. My mother died due to complications from Osteoporosis so this is of critical importance to me. I had tried manufactured ones before I found these. They did not help me at all like these have.