I began to have problems like depression and anxiety about 11 years ago. I went to a physician and had yearly tests done - blood work, etc. She recommended trying the transdermal hormones. I purchased a saliva test and the results showed that I was deficient in several hormones. I began taking very small amounts of two hormones. Within a week, I felt surprisingly better. I couldn't believe the difference. I am required to have blood work, a mammogram, and a physical checkup every year to monitor. I have never had any problems at all since 2009. I would really not feel as well as I do without the small amount of hormones I use. I hope these compounded hormones are not discontinued.