I began hormone replacement therapy over 30 years ago post hysterectomy and removal of ovaries. I was on high doses of premarin for many years. When I ceased the premarin my menapausal symptoms returned in spades - severe hot flashes, inability to sleep and to focus. I began using bioiedentical hormone creams 10 years ago and all symptoms abated. I am currently taking estradiol and testosterone cream as well as progesterone troches. I am healthy and feel totally normal. I feel the compounded hormones are eay to use, easy to adjust doses to minimum requirements and healthier.