I am unable to take hormone replacement therapy pills since they contain progesterone. Progesterone makes me feel suicidal, even though I am not. It causes my body to feel hopeless, stresses, and in a state that makes me not function. The pellets eliminate my sleepless nights. My hot flashes, profuse sweating, improves my mood and ability to function. These pellets have been a lifesaver. I have a full-time career and would not be able to function without them.