I am an advocate of compounded medications in general because I have Celiac Disease and have been made very ill by regular prescription drugs so I get all of my prescriptions at my compounding pharmacy. This way I know exactly what is in them. I've not had any adverse reactions. I have chemical allergies also and this has been important for the bioidentical hormone cream and thyroid Rx as well. They both work very well and consistently as well. Since switching to bioidentical thyroid, I have been able to drop the dosage because it has worked so much better.