I am a 68 year old female, who suffered from insomina, fatigue, headaches, and mood swings this went on for many years, I was using as natural as possible creams on the market, they would help short term. I was lucky enough to find a MD who did all my hormone levels and based on the results compounded a mixture especially for my levels. I felt within a week, normal, as if I woke up from a long sleep. These specialized compounds must be kept, we are all very different people and should not be lumped together for hormone therapy. DO NOT DO AWAY WITH COMPOUNDING. You will ruin so many stable women who depend on the specialized creams and pills.