After a hysterectomy in 2001, I began to take Rx hormone replacement therapy first as a patch and later as a cream the result was MULTIPLE breast lumps! Not to bore you with all the in-between but finally, one of my doctors suggested speaking with a compound pharmacist who in my mind saved my life! He figured out that I was estrogen dominant and was able to compound me a formula of HRT that best suited me and as a result NO breast lumps. Fast forward 22 years when a nurse practitioner decided to take me off the HRT...worth a try. The result...incontinence!. I went through multiple uncomfortable evaluations and tried multiple Rx with a urologist. In the end, it was decided that I should go back on my compounded HRT...the results were positive...no more incontinence, and no more breast lumps. If compounding HRT is no longer an option I don't know what I will do.